Medical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.

Cytokines are polypeptides released by activated vertebrate blood cells which have profound effects on other blood cells and which have hormone‐like properties affecting other organ systems as well. In recent years a wide variety of these mediators has been isolated and characterized. Many of these molecules have subsequently been cloned and expressed in E. coli. The tremendous importance of these proteins to host immune and non‐specific defense systems along with the striking similarities of their properties among different species suggested to (...) us that cytokines may have been proteins that have been conserved through evolution. Investigations of the evolution of cytokines will help us decipher the complex cellular, humoral and molecular interactions that regulate host defenses. Studies of the invertebrates will shed light on the phylogenetic emergence of these molecules as well. (shrink)

Die Frequenzkurven, die die lebendige Substanz charakterisieren, können als eine statische Beschreibung oder als das Ergebnis einer Entwicklung betrachtet werden.Im ersten Falle akzeptiert man ohne weiteres die gegebenen Verteilungen und man versucht, ihnen durch mathematische Gleichungen, die keine unmittelbare Wirklich-keitsbedeutung haben, nahezukommen. Das kausale Denken wird hier ausgeschaltet oder man gibt sich wenigstens mit nur sehr groben Analogien zufrieden.Verschiedene Methoden über die Genese der Frequenzkurven werden besprochen; dabei wird gezeigt, dass die Mehrheit der Fälle auf Hypothesen beruht, die biologisch wenig (...) begründet sind. Eine Ausnahme davon macht die Theorie vonJ. C. Kapteyn, weil er den Vorgang des Wachstums in die Genese einbezieht. Seine Methode weiter ausbauend kann man sich vorstellen, dass die Genese einer Frequenzkurve in erblich homogenem Pflanzenmaterial durch Variation der Wachstumsgeschwindigkeit zustandekommt.Auf solche Weise kann man in einem Koordinatensystem mit Länge und Zeit als Koordinaten ein “Deviationsraster” konstruieren.In einem experimentell untersuchten Fall ergab die graphische Methode mit völlig ausreichender Genauigkeit die schon gefundene Frequenz.Les courbes de fréquence qui caractérisent la matière vivante, peuvent être considérées ou comme une description statique ou bien comme le produit d'un développement.Dans le premier cas on accepte les distributions obtenues et on essaie de s'en rapprocher par des équations mathématiques qui n'ont pas une réalité effective. On ne recherche plus la causalité ou alors on se contente le plus souvent d'analogies très grossières.Les auteurs traitent des diverses méthodes de la genèse des courbes de fréquence et démontrent que la plupart des cas reposent sur des hypothèses qui ont peu de fond biologique. La théorie deM. J. C. Kapteyn fait exception parcequ'il introduit le processus de croissance dans la genèse. En poursuivant plus loin dans sa méthode on peut se figurer que la genèse d'une courbe de fréquence de plantes homogènes par hérédité s'expliquerait par des variations de vitesse de croissance.De cette façon on peut construire une “grille de déviation” dans un système en prenant longueur et temps comme coordonnées.Dans un cas essayé expérimentalement ce graphique donnait avec une exactitude assez grande la distribution de fréquence déjà trouvée. (shrink)

The central project of the Critique of Pure Reason is to answer two sets of questions: What can we know and how can we know it? and What can't we know and why can't we know it? The essays in this collection are intended to help students read the Critique of Pure Reason with a greater understanding of its central themes and arguments, and with some awareness of important lines of criticism of those themes and arguments.

Hubert Dreyfus’s work in the phenomenology of agency is distinctive for the privileged and central position he gives to our ability to navigate the everyday world. Drawing on the existential-phenomenological tradition—particularly the work of Heidegger and Merleau-Ponty—Dreyfus characterizes skillful embodied engagement with the world (skillful coping) as the paradigmatic instance of human intelligence and agency. He uses the notion of skillful coping to push against the emphasis on deliberation he finds in the traditional view of human agency. One of (...) Dreyfus’s central claims is that the complex understanding involved in skillful coping need not be highly reflective. -/- Dreyfus connects the ability to respond to the particular significances of a concrete situation with typically existential concerns, such as authenticity. The way Dreyfus connects skillful coping with authenticity exemplifies his syncretic approach in which he synthesizes and, arguably, extends the work of thinkers such as Heidegger and Merleau-Ponty. -/- The concluding section examines one worry about Dreyfus’s characterization of expertise within the skillful coping paradigm. Specifically, does Dreyfus’s rejection of the tradition’s emphasis on deliberation lead him to excessively minimize the role of deliberation as one develops and expands expertise? My suggestion is that there is space for such deliberate learning and skill development for experts within the framework Dreyfus proposes. To flesh out the place of deliberate learning, I draw on both Dreyfus and Merleau-Ponty to suggest how intentionally (and deliberately) trying to live in a certain way is not at odds with but is ultimately crucial for the expertise of absorbed, fluid, and skillful coping in a practical world. (shrink)

A Companion to Phenomenology and Existentialism is a complete guide to two of the dominant movements of philosophy in the twentieth century. Written by a team of leading scholars, including Dagfinn Føllesdal, J. N. Mohanty, Robert Solomon, Jean–Luc Marion Highlights the area of overlap between the two movements Features longer essays discussing each of the main schools of thought, shorter essays introducing prominent themes, and problem–oriented chapters Organised topically, around concepts such as temporality, intentionality, death and nihilism Features essays on (...) unusual subjects, such as medicine, the emotions, artificial intelligence, and environmental philosophy. (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

The COVID-19 pandemic’s disproportionate harm to racialized communities and increased public attention to the deaths of Black people at the hands of police (Elijah McClain, Breonna Taylor, George F...

The theory of cultural evolution proposed by economist Friedrich August von Hayek is without doubt the most harshly criticized component in his highly prolific intellectual corpus. Hayek depicted the emergence of the market order as the unintended consequence of an evolutionary process in which groups whose rules of behavior led to a comparative increase in population and wealth were favored over others. Key to Hayek’s theory was the claim that the rules of the market, on which modern civilization relies, evolved (...) at the meta-individual level and therefore surpass human reason. Hayek believed that his theory provided scientific explanation for the superiority of the market order over rational planning. In this article, I conduct a selective comparison between Hayek’s and Darwin’s theories of cultural group selection and analyze the role that demographic growth and reason play in their respective accounts. I first present Hayek’s theory of cultural group selection, its sources of inspiration, and its important place in his intellectual legacy. I then compare Hayek’s claims to Darwin’s views and highlight fundamental differences in their evaluation of the role of reason in moral evolution. Finally, I offer some comments concerning the place assigned to demographic growth in Hayek’s theory and his over-reliance on economics in explaining cultural evolution. (shrink)

In at least two of his writings, F. S. C. Northrop some time ago suggested an interpretation of the spiritual foundations of Oriental and Occidental civilization which he used as a basis for understanding, among other things, their differing approaches to moral and legal order. Rooted primarily in Biblical and Greek sources, the West, he said, has concentrated on and developed the theoretic component of experience. This component is one wherein the nature of things is taken to be, not the (...) directly observable material of sense and immediate experience, but rather that which is designated by theory through the rational construction of hypotheses and theories. Nature, so to speak, is not the nature found in the directly experienced, but that postulated or inferred by reason and science as lying “behind” or “above” direct experience and accounting causally for it. (shrink)

This study examined the relationship between various aspects of religiosity, fasting, praying, and abjuration) on depression severity and hopelessness in Turkish-Muslim university students. The Beck Depression Inventory and Beck Hopelessness Scale was administered to 634 students. The findings showed internal experience of the existence of God and frequency of performing namaz differentiated depression severity. As having an internal connection to God reduced depression severity, increased frequency of performing namaz was associated with higher levels of depressive symptomatology. Depression severity (...) varied according to the fasting habits in a nonlinear fashion. Individuals who never fasted had the lowest levels of depression, whereas individuals who sometimes fasted had the highest levels of depression. Depression severity did not vary according to the frequency of prayer and abjuration. A decrease in hopelessness was observed among individuals who experienced a strong connection to God. Those who never prayed and always prayed showed comparable levels of hopelessness. Levels of hopelessness did not vary according to the frequency of performing namaz, fasting, or abjuration. The findings partially indicated that intrinsically religious individuals had lower levels of depression and hopelessness. No linear relationships were observed between depression and hopelessness and patterns of performing namaz, fasting, praying, and abjuration. (shrink)

The last decades have seen a rising philosophical interest in the phenomenology of skill acquisition. One central topic in this work is the relation between the athlete's background capacities and foreground attention as an invariant feature of skilful movements. The purpose of this paper is to examine further this gestalt relation from the perspective of Merleau-Ponty's phenomenological account of embodied learning and a classical notion from philosophy of sport, namely ?sweet tension of uncertainty of outcome?. In the first part we (...) will explicate how Merleau-Ponty understands embodied learning as a form of gestalt switch that allows the athlete to perceive the world more meaningfully in relation to an ongoing movement project. That is, a skilled athlete perceives more and better opportunities for actions. In the second part, we revisit the classical notion of ?sweet tension of uncertainty of outcome? developed by Kretchmar. This phrase is attributed to the indeterminate back and forth rallies between sport contestants, and to persons facing a sport situation that produces an ambiguity as to whether one will succeed in one's task. In the third part, we then juxtapose Merleau-Ponty's notion of embodied learning and the notion of sweet tension from philosophy of sport in order to draw out the relations between the two notions. In addition, in much of the philosophical work on skill acquisition (for instance in Merleau-Ponty and his much-cited commentator, Hubert Dreyfus) the distinction between everyday skills (such as walking and opening doors) and sport skills is collapsed. Our discussion aims to show that by introducing the notion of ?sweet tension? to the literature on phenomenology of skill acquisition, we are able to highlight a phenomenological difference between everyday skills and sport skills. (shrink)